Small Proline Rich Like Protein 3A (SPRL3A)

By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3C, which they called LEP15. RT-PCR detected strong LEP15 expression in human esophagus, but not in skin or heart.Using real-time PCR, Jackson et al. (2005) detected very low LCE3C expression in human skin. Low expression was also detected in internal epithelia, including esophagus and tongue, but not in vulva.Wang et al. (2001) cloned mouse Lce3c, which they called Eig3. RT-PCR detected Eig3 expression in mouse stomach and epidermis, and it was overexpressed in keratinocytes expressing E2f1 (189971) and E2f4 (600659). Eig3 expression was highly increased in mouse skin papillomas, but not in squamous carcinomas