Triggering Receptor Expressed On Myeloid Cells 1 (TREM1)

TREM-1 is a Type I membrane protein that contains an immunoglobulin-like V-type domain. An alternatively spliced protein variant may be secreted. TREM-1 is expressed in monocytes and neutrophils but not in lymphocytes, dendritic cells or other cell types. TREM1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 is a glycoprotein that is reduced by deglycosylation, in agreement with the predicted molecular mass. TREM-1 is an activating receptor of the Ig superfamily that is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes). TREM1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines.