Tubulin Beta 2C (TUBb2C)

Lewis et al. (1985) cloned the tubulin beta-2 isoform gene. The beta-2 gene is expressed as a 1.8-kb mRNA, and the sequence encodes a predicted 445-amino acid protein. Lewis and Cowan (1990) stated that the mouse homolog of beta-2, M-beta-3, is expressed abundantly in testis and at lower levels in many other tissues.Lewis and Cowan (1990) reviewed the beta-tubulin gene family. In humans, this family consists of 15 to 20 dispersed genes, many of which are processed pseudogenes. The positions of the first 2 introns are identical among members of the human and chicken gene families. Within a vertebrate species, the genes are distinguished by their C-terminal region. The amino acid sequence differences show varying degrees of conservation across species, depending on the isotype.