Actin Binding LIM Protein 3 (ABLIM3)

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer .RT-PCR ELISA detected highest expression in adult liver, with moderate expression in all other adult and fetal tissues examined except adult pancreas and testis, which showed little to no expression. Expression was high in cerebellum and moderate in all other adult brain regions examined.The deduced protein contains 4 LIM domains, a C-terminal VHD domain, and a putative nuclear localization signal. Mouse and human ABLIM3 share 98% amino acid identity. ABLIM3 is conserved in vertebrates, but not in invertebrates.