Actin Related Protein 2/3 Complex Subunit 1A (ARPC1A)

ARPC1A encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.Using 1 of these ESTs, they isolated a full-length HeLa cell cDNA encoding ARPC1A, a Sop2-like protein, which they named SOP2HS. The deduced 370-amino acid ARPC1A protein contains beta-transducin repeats.