Actin Related Protein 2/3 Complex Subunit 5 Like Protein (ARPC5L)

ARPC5L belongs to the ARPC5 family. May be a component of the Arp2/3 complex in which it may replace ARPC5. May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.ARPC5 encodes one of seven subunits of the human Arp2/3 protein complex. ACTR1A encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.