Apolipoprotein A2 (APOA2)

Apolipoprotein A-II is a protein , which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.Apolipoprotein A-II, like apolipoprotein A-I (APOA1), is a major apolipoprotein in high density lipoprotein (HDL).Apolipoprotein A-II is the second most abundant protein of high density lipoprotein particles. Warden et al. (1993) showed that in both mice and humans, the APOA2 gene is linked to a gene that controls plasma levels of apoA-II and that the APOA2 gene or its product influences, by an unknown mechanism, plasma levels of free fatty acids (FFA).