Calmodulin Like Protein 3 (CALML3)

CALML3, the deduced 148-amino acid protein contains 4 helix-loop-helix Ca(2+)-binding motifs and shares 85% identity with vertebrate calmodulin. Northern blot analysis detected no expression in fibroblast, teratoma, or erythroleukemia cell lines. CLP was expressed exclusively in the epithelium of the tissues surveyed and was most abundant in thyroid, breast, prostate, kidney, and skin. CLP expression appeared to increase in stratified epithelium during differentiation, as illustrated in skin, where CLP staining intensified from the basal through the spinous to the granular layers.Significant differences between the electric surface potentials at the target protein-binding regions of CLP and calmodulin suggested that the ranges of CLP and calmodulin target proteins do not fully overlap.