Calmodulin Like Protein 5 (CALML5)

Calmodulin Like Protein 5 is a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so.Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.