Leiomodin 2 (LMOD2)

By searching EST databases for sequences similar to TMOD, Conley et al. (2001) cloned LMOD2, which they designated CLMOD. The deduced 547-amino acid protein contains a long C-terminal polyproline sequence. LMOD2 shares 89% identity with the mouse Lmod2 protein. Northern blot analysis detected a 2.7-kb transcript expressed exclusively in heart and skeletal muscle. RNA dot blot analysis showed expression only in fetal and adult heart and adult skeletal muscle.Conley et al. (2001) determined that the LMOD2 gene contains 3 exons and spans about 10 kb. Intron 1 spans more than 5 kb. By genomic sequence analysis, Conley et al. (2001) mapped the LMOD2 gene to chromosome 7q31-q32.