Natriuretic Peptide Receptor 3 (NPR3)

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3 encoded one of the family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.ANPRC gene to chromosome 5 by use of human-specific PCR primers identified by screening a human primer panel on parental DNA samples (shotgun primer screening). The gene was regionalized to 5p14-p13 by in situ hybridization.A single CNP molecule is bound in the interface of an NPR-C dimer, resulting in asymmetric interactions between the hormone and the symmetrically related receptors.