C-Type Lectin Domain Family 2, Member A (CLEC2A)

CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors. PILAR interacted with CD161 (KLRB1). RT-PCR analysis showed that T-cell activation induced transient expression of PILAR in CD8 T cells, and flow cytometric analysis demonstrated expression of PILAR on activated CD4 T cells. Increased expression of PILAR on antigen-presenting cells enhanced T-cell proliferation by increasing survival through enhanced expression of antiapoptotic proteins in a CD161-dependent manner.PILAR was expressed by 7 to 10% of CD4 T cells from 2 samples of inflammatory synovial fluid, suggesting a role in joint inflammation pathogenesis.PILAR has a central role in modulating the extent of T-cell expansion.