Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6)

CEACAM6 acted as a receptor for AIEC adhesion and was upregulated in the ileal mucosa of CD patients compared to colonic mucosa or to controls. In vitro studies showed increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC. Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. CEACAM6 blocked adenovirus trafficking to the nucleus through the SRC pathway, interfering with cancer cell cytoskeleton and reducing adenoviral infection. Knockdown of CEACAM6 with small interfering RNA significantly increased adenovirus replication and antitumor efficacy of oncolytic adenovirus in a mouse xenograft tumor model.