Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM)

CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.The 1,225-amino acid human protein and the rat protein have identical domain structures in their extracellular regions and highly related intracellular regions. The consensus sequences of the Ig- and FNIII-like domains are conserved, as are the 10 N-glycosylation sites. Except for the signal sequence, which was absent from the human cDNAs cloned, human CDON shares 81% overall amino acid identity with rat Cdon.