Cytokine Receptor Like Factor 3 (CRLF3)

CRLF3, Belongs to the cytokine receptor-like factor 3 family. Contains 1 fibronectin type-III domain. Expressed in skin and squamous cell carcinoma (SCC) and in lesion actinic keratosis (AK).Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction. Sequence analysis predicted that the 371-amino acid type I transmembrane protein contains an N-terminal signal peptide, 4 potential N-linked glycosylation sites, 2 of 4 conserved cysteine residues, and a PSDWS sequence in place of the hallmark WSXWS motif.