EGF Like Module Containing Mucin Like Hormone Receptor 1 (EMR1)

EMR1 encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.EMR1 contains the 7 hydrophobic segments and characteristic residues that allow the protein to be readily aligned with the various hormone receptors in the family. At the N terminus of the predicted mature protein, there are 6 EGF-like modules which are separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.