Free Fatty Acid Receptor 3 (FFAR3)

The physiologic responses to galanin (GAL) are mediated through specific membrane receptors called GALRs, which are members of the G protein-coupled receptor (GPCR) family. Sawzdargo et al. (1997) amplified human genomic DNA using PCR with degenerate primers based on conserved sequences of human and rat GALR1 and rat Galr2 .  The GPR41 gene has no introns. GPR41 encodes a predicted 346-amino acid GPCR containing 7 transmembrane domains, 1 glycosylation site, 1 PKC phosphorylation site, 2 PKA/PKC phosphorylation sites, and 1 palmitoylation site, which is located in the C-terminal domain. The GPR41 protein shares 98% amino acid identity with GPR42 but little similarity with GALRs.