G Protein Coupled Receptor 107 (GPR107)

G protein-coupled receptors (GPCRs) comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses.Analyzing the RNA editing pattern of LUSTR1 pre-mRNA revealed additional intronic editing sites, one of which represents the splice acceptor adenosine (AG to IG) in intron 15. Editing at this position is predicted to lead to the exclusion of the Alu exon, indicating that the alternative splicing of exon 15a might be coregulated by RNA editing of its splice junction. This is the first documented example where A-to-I RNA editing acts to destroy a pre-mRNA splice signal. A picture similar to LUSTR1 emerges from analysis of the gene for human inhibitor of BTKI.