G Protein Coupled Receptor 119 (GPR119)

GPR119 is expressed predominantly in the pancreas and gastrointestinal tract in rodents and humans, as well as in the brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate incretin and insulin hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes. The deduced protein shares 27% homology with dopamine receptor-1 (see 126449). RT-PCR detected ubiquitous GPR119 expression.The deduced 335-amino acid proteins assume a classic 7-transmembrane (TM) topology and share 82% amino acid identity. They contain the characteristic DRY motif in the intracellular side of TM3 and an NSxxNPxxY motif in TM7.