G Protein Coupled Receptor 125 (GPR125)

GPR125, the deduced 1,178-amino acid protein contains an N-terminal leucine-rich repeat followed by an immunoglobulin domain, a hormone-binding domain, and a GPS (G protein-coupled receptor proteolytic site) domain. It also has a long serine- and threonine-rich region predicted to form a mucin-like stalk. The C-terminal portion contains 7 transmembrane domains. There are conserved cysteines in the hormone-binding domain and in the predicted extracellular loops 2 and 3 that were predicted to form disulfide bridges, and there are numerous putative N-glycosylation sites throughout the molecule. GPR125 ESTs were detected in cDNA libraries from a wide variety of tissues, predominantly from brain.GPR125 gene contains 16 exons and spans 59.1 kb.