G Protein Coupled Receptor 137B (GPR137B)

TM7SF1, a gene that is transcriptionally upregulated during kidney development. RT-PCR detected 3 alternatively spliced TM7SF1 transcripts, which the authors named TM7SF1-long (TM7SF1L), TM7SF1-intermediate (TM7SF1I), and TM7SF1-short (TM7SF1S).Northern blot analysis detected an approximately 2.4-kb TM7SF1 transcript at highest levels in human kidney and heart, with lower levels detected in brain and placenta. Additional experiments found TM7SF1 expression in spinal cord, caudate nucleus, and putamen. Studies on Wilms tumor samples showed variable TM7SF1 expression, ranging from nearly undetectable levels to an abundant level of expression comparable to that of adult kidney tissue.