Gastric Inhibitory Polypeptide Receptor (GIPR)

GIPR encodes a predicted 466-amino acid protein with 79% identity to the rat homolog and 41% identity to human glucagon-like peptide receptor. GIP receptor is a member of the secretin-vasoactive intestinal polypeptide family of G protein-coupled receptors. GIP receptor mRNA is present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions. The findings suggest that GIP may have previously undescribed actions; for example, GIPR localization in the adrenal cortex suggests that GIP may have effects on glucocorticoid metabolism. Furthermore, neither GIP nor its effects have been described in the central nervous system.