IGF Like Family Receptor 1 (IGFLR1)
Английские синонимы
TMEM149; U2AF1L4; Transmembrane Protein 149; U2 RNU2 Small Nuclear RNA Auxiliary Factor 1-Like 4
Psoriasis is a human skin condition characterized by epidermal hyperproliferation and infiltration of multiple leukocyte populations. IGFL1, was uniquely and significantly induced in psoriatic skin samples. In vitro IGFL1 expression was up-regulated in cultured primary keratinocytes stimulated with tumor necrosis factor α but not by other psoriasis-associated cytokines.TMEM149 is an uncharacterized gene with structural similarity to the tumor necrosis factor receptor family. is expressed primarily on the surface of mouse T cells. The connection between mIGFL and IGFLR1 receptor suggests mIGFL may influence T cell biology within inflammatory skin conditions.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
