Membrane Spanning 4 Domains Subfamily A, Member 7 (MS4A7)

MS4A family proteins share structural similarity, amino acid sequence homology, and chromosomal location. They contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions.MS4A7 encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. MS4A is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. MS4A is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.