Trace Amine Associated Receptor 5 (TAAR5)

PNR encodes a deduced 338-amino acid protein with a molecular mass of 38.3 kD. It contains the characteristic 7-transmembrane domain of G protein-coupled receptors and a potential N-glycosylation site. It shares 35% sequence identity with the rat 5-HT-1D receptor and 34% and 33% sequence identity with the alpha-2-adrenergic receptor and the dopamine D2 receptor, respectively. Northern blot analysis demonstrated almost exclusive expression of a major 4.2-kb PNR transcript in skeletal muscle and selected brain tissues, including amygdala, hippocampus, caudate nucleus, thalamus, and hypothalamus. Weak expression was found in substantia nigra, but no expression was found in corpus callosum or subthalamic nucleus. Some minor transcripts were also found in several brain tissues.