Amprolium (APL)

The addition of liquid amprolium to the drinking water on days when medicated (amprolium) ration was not fed in a restricted feeding (skip-a-day) program improved protection against a primary exposure to Eimeria acervulina and Eimeria tenella, yet still allowed for the development of protective immunity to subsequent challenge. With E. tenella, the best protection, as measured by reduction of lesion score, was provided by amprolium given in the drinking water on alternate days to feed medication when compared with the use of amprolium only in the feed or liquid amprolium at less frequent intervals (every second or third nonfeeding day). With Eimeria maxima, amprolium in the feed did not significantly lower lesion score compared with the score in unmedicated pullets; however, the further addition of amprolium to the drinking water did.