Apigenin (AG)

Apigenin has been shown to prevent renal damage caused by cyclosporin in rats, associated with reduced expression of the cell death mediator bcl-2 in histopathological sections. Cyclosporine A enhances the expression of transforming growth factor-β in the rat kidney, which signifies accelerated apoptosis. Therefore, transforming growth factor-β and apoptotic index may be used to assess apigenin and its effect on cyclosporine A-induced renal damage. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property.