Cefadroxil (CFR)

Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in gram-positive and gram-negative bacterial infections. It is a bactericidal antibiotic. Cefadroxil is almost completely absorbed from the gastrointestinal tract. After doses of 500 mg and 1 g by mouth, peak plasma concentrations of about 16 and 30 micrograms/mL respectively are obtained after 1.5 to 2 hours. Although peak concentrations are similar to those of cefalexin, plasma concentrations are more sustained. Dosage with food does not appear to affect the absorption of cefadroxil. About 20% of cefadroxil is reported to be bound to plasma proteins. The plasma half-life of cefadroxil is about 1.5 hours and is prolonged in patients with renal impairment.  Cefadroxil is widely distributed to body tissues and fluids. It crosses the placenta and appears in breast milk.