Fisetin (FST)

Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation. Fisetin is a potent sirtuin-activating compound (STAC), an agent that modulates sirtuins. Therefore, it is a caloric restriction mimetic candidate, a drug that has been shown to be able to alleviate aging effects in certain model organisms, such as the yeast S. cerevisiae, the nematode C. elegans and the fruit fly Drosophila melanogaster. Whether such effects can be replicated in humans and other mammals is currently still not entirely clear and remains an issue of scientific research and debate. Similar to many other flavonoids, such as the structurally related flavonol quercetin, fisetin is a potent antioxidant.