Luteolin (LT)

Luteolin is a flavone, a type of flavonoid. Like all flavonoids, it has a yellow crystalline appearance. Luteolin has been studied in several preliminary in vitro scientific investigations. Proposed activities include antioxidant activity (ie. scavenging of free radicals), promotion of carbohydrate metabolism, and immune system modulation. Other in vitro studies suggest luteolin has anti-inflammatory activity, and that it acts as a monoamine transporter activator, a phosphodiesterase inhibitor, and an interleukin 6 inhibitor. In vivo studies show luteolin affects xylazine/ketamine-induced anesthesia in mice. In vitro and in vivo experiments also suggest luteolin may inhibit the development of skin cancer. Importantly, the therapeutic value of the above findings is unclear, and will remain so until further detailed in vivo, toxicity, and clinical studies are performed.