Taurolidine (TRD)

Taurolidine ([bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane) is a drug with antimicrobial and anti-lipopolysaccharide properties. Derived from the amino acid taurine, its immunue modulatory action is reported to be mediated with priming and activation of macrophages and polymorphonuclear leukocytes.Taurolidine has been used to treat patients with peritonitis and as an antiendoxic agent in patients with systemic inflammatory response syndrome. Additionally, taurolidine demonstrates some anti-tumor properties, with positive results seen in early-stage clinical investigations using the drug to treat gastrointestinal malignancies and tumors of the central nervous system.Taurolidine has been investigated for the prevention of central venous catheter-related infections, and there is ample evidence that the addition of taurolidine significantly decreases infection rates.