Thiocolchicoside (TCC)

Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals. This mechanism of action would be expected to induce withdrawal symptoms in gabaminergic dependent individuals, including the potentially lethal delerium tremens. Thiocolchicoside is broken down in the body to a metabolite called M2 or SL59.0955 that could damage dividing cells therefore inducing toxicity in the embryo, neoplastic changes and fertility reduction in males. Therefore recommended oral dose should not exceed 7 days and intramuscular dose duration should not exceed 5 days.