Tianeptine (TNP)

Tianeptine is a drug used for treating major depressive episodes. It has structural similarities to the tricyclic antidepressants, but it has different pharmacological properties. Formerly it was called a Serotonin Reuptake Enhancer. Newer research suggests that Tianeptine acts through indirect alteration of AMPA and NMDA glutamate receptor activity and seems to involve altered neuroplasticity and release of BDNF. Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine and its possible interaction with adenosine A1 receptors.