Yohimbine (Yoh)

Yohimbine is a mild MAOI with stimulant and aphrodisiac effects. It is sold as prescription medicine in pure form for the treatment of sexual dysfunction. Yohimbine was explored as a remedy for type 2 diabetes in animal and human models carrying polymorphisms of the α2A-adrenergic receptor gene. Yohimbine primarily acts as an antagonist of α2 receptors. Additionally, it inhibits the function of monoamine oxidase enzymes, although it is not clear if it is a RIMA, MAOA, or MAOB inhibitor. RIMAs, like moclobemide (an antidepressant), do not require dietary restrictions. Many people have been supplementing with yohimbine on normal diets (containing tyramine and phenylalanine, found in most cheeses and fish respectively) with no adverse effects. However, tyrosine failed to potentiate the effect of yohimbine except for somewhat augmenting the increase in DHPG.