A Disintegrin And Metalloproteinase With Thrombospondin 17 (ADAMTS17)

ADAMTS17 is a member of the large ADAMTS family of zinc-dependent proteases. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined. The protein contains an N-terminal signal peptide, followed by a propeptide; a metalloprotease catalytic domain that includes the Zn-binding motif; a disintegrin-like domain; a central thrombospondin I (THBS1)-like motif; a cysteine-rich domain; a spacer region; 3 C-terminal THBS1 repeats; and a protease-lacunin (PLAC)-like domain. It also has 7 N-glycosylation sites. ADAMTS17 shares 56% sequence identity with ADAMTS19, including 88% identity within the catalytic domains. PCR analysis revealed that ADAMTS17 is expressed in fetal lung and in adult brain, prostate, and liver.