Alcohol Dehydrogenase 6 (ADH6)

Alcohol dehydrogenase 6 is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5""" UTR, which is a steroid hormone receptor binding site. The deduced amino acid sequence of the open reading frame of this gene shows about 60% positional identity with other known alcohol dehydrogenases. This gene may have a distinct physiologic function.The ADH6 sequence shows approximatley 60% positional identity with known human ADHs, suggesting interclass similarity within the human ADH family.