Aldehyde Dehydrogenase 3 Family, Member B1 (ALDH3B1)

This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb which is highly expressed in kidney and lung. The functional significance of this gene as well as the cellular localization of its product are presently unknown. The full-length human kidney cDNA of ALDH7 is 2,791 bp long and contains an open reading frame encoding 468 amino acids.The deduced sequence of ALDH7 was longer than that of human stomach ALDH3 by 15 amino acids at the C terminus. The degree of identity between the 2 isozymes was 52% with a positional alignment of 453 amino acids. Northern blot analysis demonstrated that lung is another major tissue expressing ALDH7.