Aldolase C, Fructose Bisphosphate (ALDOC)

Aldolase C, fructose-bisphosphate is a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.Rottmann et al. determined that the gene structure of ALDOC is the same as that in other aldolase genes in birds and mammals, having 9 exons separated by 8 introns, all in precisely the same positions, with only the intron sizes being different. One of the exons is noncoding. The entire gene is approximately 4 kb long. Buono et al. presented the complete nucleotide sequence of ALDOC.