Apolipoprotein A1 Binding Protein (APOA1BP)

APOA1BP contains an N-terminal signal peptide for translocation into the endoplasmic reticulum, a putative signal sequence cleavage site, and several putative phosphorylation and O-glycosylation sites. The processed mature protein has a calculated molecular mass of 29.1 kD. Human APOA1BP shares 88.2 to 89.5% amino acid identity with mouse, bovine, and porcine Apoa1bp. RNA dot blot analysis revealed abundant APOA1BP expression in all adult and fetal tissues investigated. Highest expression was in kidney, apex of heart, liver, thyroid gland, adrenal gland, and testis. APOA1BP was also expressed in all cell lines examined. APOA1BP was also detected in cerebrospinal fluid (CSF) and urine of healthy volunteers, but not in normal serum samples.