Apolipoprotein O Like Protein (APOOL)

Apolipoproteins are a homologous gene family that is mostly expressed in liver tissue . They are the major components of HDLs and LDLs so they are responsible for transporting fatty acids and cholesterol in the blood circulation and they bind receptors, which control the intake of the lipoproteins. Many apolipoprotein gene family members are located in gene clusters on different chromosomes. There are eight well-characterized apolipoproteins: APOA1, APOA2, APOA5, APOB, APOC1, APOC2, APOC3, and APOE. Some of them are already identified as PPAR target genes. Not so well known apolipoproteins are: APOA, APOC4, APOD, APOH, APOL, APOM, APOO and APOOL. APOO and APOOL are expressed only in HepG2 cell line. APOO gene expression is not affected by PPAR ligands. APOOL is induced after 4 and 6 h with PPARα ligand.