Arachidonate-5-Lipoxygenase Activating Protein (ALOX5AP)

5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is bound to the nuclear membrane. FLAP is an integral membrane protein of the nucleus membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. FLAP structure consist of 4 transmembrane alpha helices, but they are found in 3’s( trimer) forming a barrel. The barrel is about 60 A high and 36 A wide.