Butyrophilin Subfamily 3, Member A2 (BTN3A2)

BTN3A2 encodes a member of the butyrophilin (BTN) family and the immunoglobulin (IG) superfamily. The gene resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other six family members, including BTN, BTN2A1, BTN2A2, BTN2A3, BTN3A1, and BTN3A3, on chromosome 6. The full-length protein encoded by this gene is a type I membrane protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Instead, the BTN3A2 transcript is truncated at its 3-prime end and encodes a protein lacking the B30.2 domain. Immunofluorescence microscopy showed surface expression of BTN3A2 in transfected HeLa and Chinese hamster ovary cells.