C-Type Lectin Domain Family 2, Member L (CLEC2L)

CLEC2 is a 32 kDa type II transmembrane glycoprotein and member of the C-type lectin like family of receptors. A splicing variant at aa 22 55 produces two isoforms for CLEC2. Human CLEC2 shares 63% aa sequence identity with mouse CLEC2. CLEC2 is expressed preferentially in liver, and is also detected in myeloid cells, platelets, and megakaryocytes. CLEC2 is the receptor for the plateletaggregating snake venom protein rhodocytin and the molecule podoplanin, a transmembrane sialoglycoprotein that, when bound to CLEC2, is involved in platelet aggregation, tumor metastasis, and lymphatic vessel formation. CLEC2 has also been shown to enhance infectivity of HIV1 by mediating HIV1 attachment and transfer by CLEC2 transfected cells and platelets.