Calmodulin Regulated Spectrin Associated Protein 2 (CAMSAP2)

CAMSAP1 has recently been reported as a protein expressed in the nervous system of mammals in neurons and astrocytes, where it is suggested to interact with intermediate filaments. Analysis of vertebrate genomes available in ENSEMBL revealed representatives of all three members of the CAMSAP gene family in each organism, but with one exception. Interestingly, the chicken only has two CAMSAP family genes, CAMSAP1 and CAMSAP2. Vertebrates have three groups of CAMSAP-family genes that segregate consistently into CAMSAP1, CAMSAP2, and CAMSAP3. In the fish, there are typically two copies of each of the three classes of gene, consistent with the known whole-genome duplication in the evolution of the bony fish. Single genes are annotated in all the invertebrates analyzed.