Capping Protein Muscle Z Line Alpha 2 (CAPZa2)

CAPZa2 is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end.The derived human alpha subunit shares 95% amino acid identity with the chicken-alpha subunit; the beta subunit is 99% identical to chicken subunit residues 1-243. The remaining portion of the human beta subunit (amino acids 244-272) diverges significantly with only 8 out of 29 C-terminal amino acids conserved between the 2 species.The human alpha-2 gene (symbolized CAPZA2) was mapped to chromosome 7q31.2-q31.3 by PCR screening of the NIGMS human/rodent somatic cell hybrid mapping panel 2 and with refinement by PCR analysis of a human chromosome 7-specific YAC library.