Cell Division Cycle Associated Protein 7 (CDCA7)

CDCA7 was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.JPO1 encodes a deduced 371-amino acid protein with a putative leucine zipper and a cysteine-rich region. Dot-blot analysis of RNA from multiple human tissues detected highest levels of JPO1 in small intestine and thymus, high levels in fetal thymus, fetal lung, colon, stomach, and appendix, and low levels in bone marrow, spleen, lymph node, and peripheral blood leukocytes. Western blot analysis identified a 47-kD JPO1 band.