Chromatin Modifying Protein 1A (CHMP1A)

CHMP1A encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. PRSM1 belongs to the gluzincin subfamily of metallopeptidases. The zincin superfamily comprises metallopeptidases that contain an HEXXH zinc-binding consensus sequence, and gluzincins have glutamic acid as a third zinc ligand. The full-length sequence of PRSM1 encodes a deduced 318-amino acid protein with an HELGH pentapeptide fitting the consensus sequence characteristic of zincins, and a glutamic acid 25 residues C-terminal of the first histidine, fitting the pattern of gluzincins for a third zinc-binding ligand.