Chromatin Modifying Protein 1B (CHMP1B)

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.The C18ORF2 gene encodes a deduced 199-amino acid protein with a predicted molecular mass of 22.1 kD. The protein is highly conserved across several species and shares 55% sequence identity with the PRSM1 gene (CHMP1A). RT-PCR analysis detected moderate expression of C18ORF2 in all tissues tested.