Chromatin Modifying Protein 4A (CHMP4A)

CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression .The deduced 223-amino acid protein has 3 coiled-coil regions, a basic N-terminal half, and an acidic C-terminal half.Northern blot analysis detected CHMP4A expression in all tissues examined, with highest levels in kidney, liver, skeletal muscle, and heart.