Chromatin Modifying Protein 4C (CHMP4C)

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression. The deduced 233-amino acid protein contains coiled-coil domains and is rich in basic and acidic residues in its N- and C-terminal halves, respectively. It shares 61% and 50% amino acid identity with CHMP4A and CHMP4B, respectively. Northern blot analysis detected a 2.1-kb transcript in heart, spleen, and kidney.